Novel designs of countercurrent chromatography (CCC) rotors have come out of 
the research of the NIH scientist, Yoichiro Ito.  Spiral disk and spiral tubing rotors are 
capable of retaining the heavy alcohol and 2-phase aqueous solvent systems useful 
for separating large molecules.  Thus proteins can be purified in non-denaturing 
solvents.  This opens up many applications for bio-molecule purification.  From the 
difficult-to-dissolve membrane proteins to the very large modified molecules, labeled 
for delivery or diagnostics, all can now be purified for optimal function.   Spiral CCC 
serves as a versatile tool for the biosynthetic chemist and chromatographer.  Now all 
types of 2-phase solvent systems can be used to separate all kinds of molecules.

CC Biotech LLC established to license the new patents from the NIH, 
is now manufacturing these new rotors for the research laboratory.  We will make 
available the tools and reagents for spiral CCC.  The essential methods and 
applications are available at this website, as well (under continuous development).  If 
there is a question or something else that you need, feel free to contact us.
-- CC Biotech has moved to a new address:
    12111 Parklawn Drive
     Rockville, MD 20852 
        Phone: 240-669-9281
and is starting a new project funded by a phase I NIH grant 'Spiral CCC for
High-Throughput Natural Products Purification' from the NCCAM Institute
-- Important new publication using the spiral disk rotor:

Single-Step Total Fractionation of Single-Wall Carbon Nanotubes

by Countercurrent Chromatography

Min Zhang, Constantine Y Khripin, Jeffrey A. Fagan, Peter McPhie, Yoichiro Ito,

and Ming Zheng, 2014 in Analytical Chemistry


CC Biotech is on SSN, ( ) see the interview--