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Instrument for spiral CCC using the STS-4 rotors and mixer-settler rotors available at CC Biotech. 
 

Photo of a mixer-settler rotor:


Preparative-laboratory scale planet centrifuge with temperature control and 500 - 1000 rpm centrifugation rate
fabricated at CC Biotech.  Turn-key instruments for sample loads of 1 g or more for natural products separation
and large molecule separation using the aqueous-aqueous two phase solvent systems suitable for proteins and
single-walled carbon nanotubes.  The STS-4 prep CCC instrument (0.9L total vol.) has application for all MW molecules.

Novel designs of countercurrent chromatography (CCC) rotors have come out of 
the research at the NIH.  Spiral disk and spiral tubing rotors are 
capable of retaining the heavy alcohol and 2-phase aqueous solvent systems useful 
for separating large molecules.  Thus proteins can be purified in non-denaturing 
solvents.  This opens up many applications for bio-molecule purification.  From the 
difficult-to-dissolve membrane proteins to the very large modified molecules, labeled 
for delivery or diagnostics, all can now be purified for optimal function.   Spiral CCC 
serves as a versatile tool for the biosynthetic chemist and chromatographer.  Now all 
types of 2-phase solvent systems can be used to separate all kinds of molecules.
CC Biotech LLC established to license the new patents from the NIH, 
is now manufacturing these new rotors for the research laboratory.  We will make 
available the tools and reagents for spiral CCC.  The essential methods and 
applications are available at this website, as well (under continuous development).  If 
there is a question or something else that you need, feel free to contact us.
 
Presentation at Pittcon Orlando FL Feb - Mar 2018
Also Short Course in Countercurrent Chromatography and Centrifugal Partition Chromatography offered at Pittcon 2018
go to Pittcon.org website for more information
 
-- CC Biotech present address:
 
    12111 Parklawn Drive
     Rockville, MD 20852 
        Phone: 240-669-9281
 
 
-- Important  publication using the spiral mixer-settler rotor:

Single-Step Total Fractionation of Single-Wall Carbon Nanotubes

by Countercurrent Chromatography

Min Zhang, Constantine Y Khripin, Jeffrey A. Fagan, Peter McPhie, Yoichiro Ito,

and Ming Zheng, 2014 in Analytical Chemistry doi.org/10.1021/ac5003189

 

Recent publications in carbon nanotube separation DOI:10.1016/j.chroma.2016.12.070 and
                                                   in natural products DOI:10.1016/j.chroma.05.027
 
 
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